CLINICAL TRIALS AND OBSERVATIONS Dasatinib as first-line treatment for adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia
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چکیده
Robin Foà,1 Antonella Vitale,1 Marco Vignetti,2 Giovanna Meloni,1 Anna Guarini,1 Maria Stefania De Propris,1 Loredana Elia,1 Francesca Paoloni,2 Paola Fazi,2 Giuseppe Cimino,1 Francesco Nobile,3 Felicetto Ferrara,4 Carlo Castagnola,5 Simona Sica,6 Pietro Leoni,7 Eliana Zuffa,8 Claudio Fozza,9 Mario Luppi,10 Anna Candoni,11 Ilaria Iacobucci,12 Simona Soverini,12 Franco Mandelli,13 Giovanni Martinelli,12 and Michele Baccarani,12 on behalf of the GIMEMA Acute Leukemia Working Party
منابع مشابه
CLINICAL TRIALS AND OBSERVATIONS Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome–positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study
1Medizinische Klinik II, Johann Wolfgang Goethe Universität, Frankfurt, Germany; 2Hospital Saint Louis, Paris Cedex, France; 3Istituto di Ematologica E Oncologica Medica, Policlinico S Orsola, Bologna, Italy; 4Department of Hematology, University Hospital, Uppsala, Sweden; 5Clinical Research Centre, Centre Hospitalier Universitaire la Milétrie, Poitiers, France; 6University of Chicago, IL; 7Dip...
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In adult Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph ALL), minimal residual disease (MRD) after stem cell transplantation (SCT) is associated with a relapse probability exceeding 90%. Starting imatinib in the setting of MRD may decrease this high relapse rate. In this prospective multicenter study, 27 Ph ALL patients received imatinib upon detection of MRD after SCT. Bcr-a...
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The BCR-ABL fusion, the molecular equivalent of the Philadelphia translocation, gains importance for treatment stratification in adult acute lymphoblastic leukemia (ALL). In this prospective study, samples from 478 patients with CD101 B-cell precursor ALL (c-ALL and pre-B ALL) underwent BCR-ABLreversetranscription–polymerase chain reaction (RT-PCR) analysis with double testing of positive sampl...
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Adrienne de Labarthe,1 Philippe Rousselot,2 Françoise Huguet-Rigal,3 Eric Delabesse,4 Francis Witz,5 Sébastien Maury,6 Delphine Réa,1 Jean-Michel Cayuela,1 Marie-Christine Vekemans,7 Oumedaly Reman,8 Agnès Buzyn,4 Arnaud Pigneux,9 Martine Escoffre,10 Yves Chalandon,11 Elizabeth MacIntyre,4 Véronique Lhéritier,12 Jean-Paul Vernant,13 Xavier Thomas,12 Norbert Ifrah,14 and Hervé Dombret1 for the G...
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The translocation (9;22) gives rise to the p190Bcr-Abl and p210Bcr-Abl tyrosine kinase proteins, considered sufficient for leukemic transformation. Philadelphia-positive (Ph ) acute leukemia patients failing to respond to initial induction therapy have a poor prognosis with few effective treatment options. Imatinib is an orally administered, potent inhibitor of the Bcr-Abl tyrosine kinase. We c...
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